Once you're familiar with the concepts, we encourage you to continue your exploration of the topics most relevant to your science project using the references listed in the Bibliography, as well as personal resources, such as your mentor and other science and math professionals, including your teachers. Instead, you're encouraged to use this guide as a means of familiarizing yourself with the general principles of experimental design. Although this guide will mention various principles of experimental design and statistical tests, it is not meant to be an exhaustive textbook. If you don't spend time thinking about the types of observations you'll be making, the likely outcomes, and how you can evaluate your data to differentiate statistically between outcomes, you might fail to carry out experiments that can actually provide you with informative data-and that would be poor science and a waste of your time! The sections below discuss techniques, tips, and resources for creating informative experimental designs. But rigorous analysis also requires careful experimental design. Other scientists in the field will be looking at your work and will expect that the data has been rigorously analyzed. Hess, Founder and President, Science BuddiesĪdvanced science projects and independent scientific research are invariably subject to much scrutiny. Keep visiting the website to learn more about such specific terms that confuses you.Sandra Slutz, PhD, Vice President of STEM Education, Science Buddies So after reading these major differences between positive and negative control, now the concepts of difference between both should be clear in your mind. Both of the controlling factors are usually used to improve the reliability of the experimental system.Both the positive and the negative controls are an important part of any experiment system.A negative control is a trial and error treatment which does not cause the desired result of the experiment.A positive control is an experimental treatment which is performed with a known factor to find the desired impact of the treatment.Major Differences between Both Positive and Negative Control In case, that an inhibition is discovered in the negative control, it indicates that something is wrong with the experiment. Hence, bacteria can grow without being inhibited. In sterile unadulterated water, there is no antimicrobial compound. So, to introduce a negative control in the system, the disk is soaked with sterile unadulterated water. In the case of the example given above, let’s say that the experiment is taking place on a disk-shaped structure. In experiments, negative control should be designed in a way so that it does not produce the desired outcome of the experiment. Negative control usually produces no response in the experiment. So, if one observes a prominent growth inhibited zone even inside the area surrounded by the positive control, it would prove that the experimental setup is working well without errors. It produces a dominant bacterial growth inhibition area inside which the test needs to be held. Therefore, by making use of such controlling factors, a researcher can identify and optimize the procedure without wasting time, effort and money.įor example, when testing a plant extract for its anti-bacterial properties, in antimicrobial substance experiment, a known anti-bacterial compound is employed as a positive control. This means, if a hit and trial method are used, the positive control will not likely produce the accurate results. A positive control is a useful proof to show that the system, reactants, and the environment, under which the experiment is taking place, are functioning without any errors. Researcher uses the controls to test the respective variations caused in the results by changing the value of these controlling factors. Thus, the primary difference between positive and negative controls lies in their result producing capabilities in the experiment.Ī positive control is an experimental control which gives the positive results (the results that lie within the expectations of the researcher). The negative control is an experimental treatment which does not lead to the expected results. A positive control is an experimental treatment which leads to the desired results just as the researcher expects. Negative and positive controls are usually described as the parameters of the experiment. What is meant by the positive and negative control and especially what is the difference between positive and negative control? Difference between Positive and Negative Control Sometime we use the terms positive and negative control. There are some rules and regulations under which this entire process gets completed. Difference between Positive and Negative Control: – Medical and scientific results or experiments are always and done under a controlled environment.
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